| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8320204 | Current Opinion in Structural Biology | 2014 | 9 Pages |
Abstract
- Hexameric nucleic-acid translocases and helicases form rings that encircle DNA or RNA.
- These motors hydrolyze ATP to power nucleic acid movement through a central pore.
- Ring loading occurs by assembly on nucleic acid strands or by opening pre-formed rings.
- Accessory domains can aid with substrate DNA or RNA recognition before loading.
- Ring loading is either self-directed or is facilitated by ancillary chaperones.
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Authors
Valerie L O'Shea, James M Berger,