| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8320520 | DNA Repair | 2016 | 26 Pages |
Abstract
The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The process is initiated by recognition of a DNA mismatch, and validated by ATP and the presence of a processivity clamp or a methylation mark. Several events in MMR promote conformational changes that lead to progression of the repair process. Here we discuss functional conformational changes in the MMR proteins and we compare the enzymes to paralogs in other systems.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Flora S. Groothuizen, Titia K. Sixma,