| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8320533 | DNA Repair | 2016 | 7 Pages |
Abstract
DNA mismatch repair (MMR) protects genome integrity by correcting DNA replication-associated mispairs, modulating DNA damage-induced cell cycle checkpoints and regulating homeologous recombination. Loss of MMR function leads to cancer development. This review describes progress in understanding how MMR is carried out in the context of chromatin and how chromatin organization/compaction, epigenetic mechanisms and posttranslational modifications of MMR proteins influence and regulate MMR in eukaryotic cells.
Keywords
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Authors
Feng Li, Janice Ortega, Liya Gu, Guo-Min Li,