Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8320546 | DNA Repair | 2016 | 8 Pages |
Abstract
We have currently entered a genomic era of cancer research which may soon lead to a genomic era of cancer treatment. Patient DNA sequencing information may lead to a personalized approach to managing an individual's cancer as well as future cancer risk. The success of this approach, however, begins not necessarily in the clinician's office, but rather at the laboratory bench of the basic scientist. The basic scientist plays a critical role since the DNA sequencing information is of limited use unless one knows the function of the gene that is altered and the manner by which a sequence alteration affects that function. The role of basic science research in aiding the clinical management of a disease is perhaps best exemplified by considering the case of Lynch syndrome, a hereditary disease that predisposes patients to colorectal and other cancers. This review will examine how the diagnosis, treatment and even prevention of Lynch syndrome-associated cancers has benefitted from extensive basic science research on the DNA mismatch repair genes whose alteration underlies this condition.
Keywords
v-raf murine sarcoma viral oncogene homolog BMMRHNPCCBRAFMSH2MSH6PMS2BRCA2TGFβ1MLH1IDLPARP1N-methyl-N’-nitro-N-nitrosoguanidineO6-methylguanine-DNA methyltransferaseMTH1human MutL homolog 1insertion/deletion loop5-FUFAPPINK1CFSMSIMNNGMGMTHRRO6-methylguaninePTEN-induced putative kinase 1siRNAVUSImmunohistochemistryIHCMEGMicrosatellite instabilitytransforming growth factor beta 1Homologous recombination repairmismatch repairColorectal cancerhereditary non-polyposis colon cancerLynch syndromeChemotherapy5-fluorouracilVariants of uncertain significancePersonalized medicinePoly(ADP-ribose) polymerase 1familial adenomatous polyposisBRCA1CRC
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Authors
Christopher D. Heinen,