Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8320648 | DNA Repair | 2015 | 8 Pages |
Abstract
- Peripheral human lymphocytes are unable to repair oxidized purines such as 8-oxoG.
- The repair of DNA single-strand breaks is slow as well.
- Activation of lymphocytes causes an induction of repair proteins and restores repair.
- The induction of repair precedes the stimulation of cell proliferation.
- Induction of the repair glycosylase OGG1 is mediated by MAP kinases and NF-YA.
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Authors
Carina von der Lippen, Sanjeeb Sahu, Marco Seifermann, Vijay K. Tiwari, Bernd Epe,