| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8320692 | DNA Repair | 2014 | 9 Pages |
Abstract
- Knock-in mice that express catalytically-inactive Polk have been established.
- Mutations at CpG and GpG sites where MMC forms cross-links were enhanced in the mice.
- DNA strand breaks induced by MMC were also enhanced in the mice.
- Polk mediates error-free bypass across MMC cross-links and averts DNA strand breaks.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Akira Takeiri, Naoko A. Wada, Shigeki Motoyama, Kaori Matsuzaki, Hiromi Tateishi, Kaoru Matsumoto, Naoko Niimi, Akira Sassa, Petr Grúz, Kenichi Masumura, Masami Yamada, Masayuki Mishima, Kou-ichi Jishage, Takehiko Nohmi,