Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8320836 | DNA Repair | 2014 | 9 Pages |
Abstract
- We review single-molecule fluorescence studies of the glycosylase search for damage.
- These studies confirm that glycosylases use sliding and distributive search modes.
- Search behavior is consistent for hOGG1, Nth, Fpg, and Nei glycosylases.
- E. coli DNA glycosylases utilize a wedge residue to search DNA for oxidative damage.
- Single-molecule studies are discussed in the context of the ensemble literature.
Keywords
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Biochemistry
Authors
Andrea J. Lee, David M. Warshaw, Susan S. Wallace,