Article ID Journal Published Year Pages File Type
8320836 DNA Repair 2014 9 Pages PDF
Abstract

- We review single-molecule fluorescence studies of the glycosylase search for damage.
- These studies confirm that glycosylases use sliding and distributive search modes.
- Search behavior is consistent for hOGG1, Nth, Fpg, and Nei glycosylases.
- E. coli DNA glycosylases utilize a wedge residue to search DNA for oxidative damage.
- Single-molecule studies are discussed in the context of the ensemble literature.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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