Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8320971 | DNA Repair | 2014 | 13 Pages |
Abstract
Double strand breaks pose unique problems for DNA repair, especially when broken ends possess complex structures that interfere with standard DNA transactions. Nonhomologous end joining can use multiple strategies to solve these problems. It further uses sophisticated means to ensure the strategy chosen provides the ideal balance of flexibility and accuracy.
Keywords
TDP1HRDCDNA-PKDNA-PKcsNAP1SSBRVWAPBZTDP2WRNXRCC4Mre11/Rad50/Nbs1Tyrosyl-DNA phosphodiesterase 1AprataxinSAP domainXLFAPLFPolynucleotide kinase/phosphataseAPTXRQCPNKPXRCC4-like factorBRCA1 C-terminalBRCTFHADSBdsDNAATRNHEJBERSCIDTdTPARPMRNataxia-telangiectasia mutateddouble-stranded DNAPIKKROSDNA damageionizing radiationdouble strand break repairbase excision repairsingle-strand break repairSETParalternative end joiningHeatATMdouble-strand breakdouble strand breaknon-homologous end-joiningforkhead-associatedHomologous recombinationDNA-dependent protein kinaseNonhomologous end joiningsevere combined immunodeficiencyReactive oxygen species
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Authors
Crystal A. Waters, Natasha T. Strande, David W. Wyatt, John M. Pryor, Dale A. Ramsden,