Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8321032 | DNA Repair | 2014 | 10 Pages |
Abstract
- The major S. pombe AP endonuclease, Apn2, binds to the inter-domain connector of Myh1.
- Apn2 and Hus1 bind overlapping but different sequence motifs on Myh1.
- Apn2 has 3â²-phosphodiesterase activity and a weak AP endonuclease activity.
- Apn2 stimulates Myh1 glycosylase activity and cleaves the AP sites generated by Myh1.
- The phosphodiesterase activity of Apn2 is stimulated by Myh1.
Keywords
Schizosaccharomyces pombePCNANth1UDGAP Endonuclease9–1–1MYH-associated polyposisBERGSTDTTMBPTHFFAMIDC7,8-dihydro-8-oxoguanineapurinic/apyrimidinicBSADNA glycosylaseUracil DNA glycosylasebovine serum albuminProliferating Cell Nuclear AntigenHumanDNA repairbase excision repairMYHdithiothreitolSaccharomyces cerevisiaePhosphodiesteraseFluoresceinYeastRate constantsmapmaltose binding proteinkobsglutathione S-transferase
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Authors
Jin Jin, Bor-Jang Hwang, Po-Wen Chang, Eric A. Toth, A-Lien Lu,