| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8321903 | The International Journal of Biochemistry & Cell Biology | 2018 | 21 Pages |
Abstract
GW182 proteins interact directly with the argonaute proteins and constitute key components of miRNA repressor complexes (miRISC) in metazoans. As argonautes are insufficient for silencing they recruit the GW182â¯s that act as scaffold proteins inducing downstream translational repression, target mRNA deadenylation and exonucleolytic mRNA degradation. Besides their role as part of repressor complexes inside the cell, they function in wide variety of cellular processes as highlighted in this review. The present review summarises and discusses in detail our current knowledge of the GW182â¯s and their role inside the cell.
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Authors
Saife Niaz, Mahboob Ul Hussain,