Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8321926 | The International Journal of Biochemistry & Cell Biology | 2018 | 36 Pages |
Abstract
Integrins are cell surface receptors that traditionally mediate cell-to-extracellular matrix and cell-to-cell adhesion. They can, however, also bind a large repertoire of other molecules. Integrin αvβ6 is exclusively expressed in epithelial cells where it can, for example, serve as a fibronectin receptor. However, its hallmark function is to activate transforming growth factor-β1 (TGF-β1) to modulate innate immune surveillance in lungs and skin and along the gastrointestinal tract, and to maintain epithelial stem cell quiescence. The loss of αvβ6 integrin function in mice and humans leads to an altered immune response in lungs and skin, amelogenesis imperfecta, periodontal disease and, in some cases, alopecia. Elevated αvβ6 integrin expression and aberrant TGF-β1 activation and function are associated with organ fibrosis and cancer. Therefore, αvβ6 integrin serves as an attractive target for cancer imaging and for fibrosis and cancer therapy.
Keywords
HSVαvβ6 integrinTGF-βamelogenesis imperfectaFMDVuPATregLAPECMERKTRMEGFRSTAT3MMPinflammationEBVPeriodontal diseaseepithelial-to-mesenchymal transformationtransforming growth factor-βEMTCancerRegulatory T cellDendritic cellsurokinase-type plasminogen activatorFibrosisExtracellular matrixmatrix metalloproteinasesignal transducer and activator of transcription 3Epstein–Barr virusFoot-and-mouth disease virusherpes simplex viruslatency-associated peptideextracellular signal-regulated kinaseEpidermal growth factor receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Leeni Koivisto, Jiarui Bi, Lari Häkkinen, Hannu Larjava,