The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition

Article ID	Journal	Published Year	Pages	File Type
8322001	The International Journal of Biochemistry & Cell Biology	2018	48 Pages	PDF

Keywords

4-PP NNMT kcat/Km nicotinamide N-methyltransferase N-methylation 1-methyl-4-phenylpyridinium ion MMP 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 4-Phenylpyridine DMSO MPP+MTT Catalytic efficiency Parkinson’s disease Substrate specificity dimethylsulphoxide Neurotoxicity Enzyme kinetics Independent variable Dependent variable Substrate inhibition Mitochondrial membrane potential

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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The kinetic analysis of the N-methylation of 4-phenylpyridine by nicotinamide N-methyltransferase: Evidence for a novel mechanism of substrate inhibition

Authors

Matthijs J. van Haren, Martin G. Thomas, Davide Sartini, David J. Barlow, David B. Ramsden, Monica Emanuelli, Fábio Klamt, Nathaniel I. Martin, Richard B. Parsons,