Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8322026 | The International Journal of Biochemistry & Cell Biology | 2018 | 35 Pages |
Abstract
Our results indicate that an adaptation of the mitochondrial energy metabolism occurs in the chlordecone angiogenic response. Finally, we showed that chlordecone induces endothelial cells angiogenesis by a cross-talk involving NADPH oxidase and mitochondrial O2âvia a NO sensitive pathways through activation of ERα. These findings propose that a molecular mechanism may partly explain the epidemiological evidence implicating chlordecone as risk factor carcinogenesis.
Keywords
CMHHIF-1ChlordeconebFGFNOSHUVECFCCPRCRERαNRF-1TFAMUCRPGC1-αEGM-2MnTMPyPFBSERRαUncoupling Control Ratiol-NAMEO2−Angiogenesissuperoxide anionEDTAEthylenediaminetetraacetic acidsodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGENADPH oxidaseEPRElectron paramagnetic resonanceRETSODfetal bovine serumHuman umbilical vein endothelial cellEndothelial cellSuperoxide dismutasehypoxia inducible factor-1nuclear respiratory factor-1mitochondrial transcription factor AVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)basic fibroblast growth factorendothelial cell growth mediumreverse electron transportMitochondrialMitochondriarespiratory control ratioNitric oxidenitric oxide synthaseEstrogen-related receptor alphaEstrogen receptor alpha
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Eid Alabed Alibrahim, Ramaroson Andriantsitohaina, Kévin Hardonnière, Raffaella Soleti, Sébastien Faure, Gilles Simard,