| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8322081 | The International Journal of Biochemistry & Cell Biology | 2018 | 37 Pages |
Abstract
We conclude that factors derived from conditioned medium of adipose-derived mesenchymal stem cells and sFRP4 significantly decreased the tumour cell viability and migration rates (MCF-7), accompanied with an enhanced apoptotic activity through inhibition of canonical Wnt signalling. Besides giving an insight to possible paracrine interactions and influence of signalling pathways, reflective of a breast tumour microenvironment, this study emphasises the utilization of cell free-secreted factors and Wnt antagonists to improve conventional anti-cancer strategies.
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Authors
Malini Visweswaran, Frank Arfuso, Rodney J. Dilley, Philip Newsholme, Arun Dharmarajan,