Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8322154 | The International Journal of Biochemistry & Cell Biology | 2017 | 10 Pages |
Abstract
Recent studies have reported that polyamines in the colonic lumen might affect animal health and these polyamines are thought to be produced by gut bacteria. In the present study, we measured the concentrations of three polyamines (putrescine, spermidine, and spermine) in cells and culture supernatants of 32 dominant human gut bacterial species in their growing and stationary phases. Combining polyamine concentration analysis in culture supernatant and cells with available genomic information showed that novel polyamine biosynthetic proteins and transporters were present in dominant human gut bacteria. Based on these findings, we suggested strategies for optimizing polyamine concentrations in the human colonic lumen via regulation of genes responsible for polyamine biosynthesis and transport in the dominant human gut bacteria.
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Authors
Yuta Sugiyama, Misaki Nara, Mikiyasu Sakanaka, Aina Gotoh, Aya Kitakata, Shujiro Okuda, Shin Kurihara,