Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8322428 | The International Journal of Biochemistry & Cell Biology | 2015 | 20 Pages |
Abstract
PTX3 could be considered as a molecular link between innate and adaptive immunity as well as between focal and circulating responses during inflammation. In fact, it modulates the functions of resident dendritic cells and circulating lymphocytes. Recent evidence demonstrates that manipulation of PTX3 may produce even opposite effects depending on which target organ is considered and the physiopathological context. In the present review we discuss the good and bad cops of PTX3 concerning multifacted effects on inflammation, innate immunity, brain diseases and tumorigenesis. Finally, a perspective on PTX3 and autophagy is provided as a convergent pathway.
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Authors
Francesco Fornai, Albino Carrizzo, Michela Ferrucci, Antonio Damato, Francesca Biagioni, Anderson Gaglione, Annibale Alessandro Puca, Carmine Vecchione,