Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8322546 | The International Journal of Biochemistry & Cell Biology | 2015 | 5 Pages |
Abstract
Cholangiocarcinoma (CCA) is a malignancy arising from the epithelial cells lining the biliary tract. Despite the existence of variation in incidence and etiology worldwide, its incidence is increasing globally in the past few decades. Surgery is the only curative treatment option for a minority of patients presented with early disease; while moderate effective chemotherapy remains the standard care for patients with locally advanced or metastatic diseases. In this article, we briefly review the molecular alterations that have been described in CCAs focusing on the role of epigenetic modification, including promoter methylation inactivation, histone modification and microRNA, in the carcinogenesis and progression of CCAs. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.
Keywords
MGMTCHFRhMLH1SMYD3DnmtDAPKSOCS-3EZH2TSGDNA methyltransferasesCpGAPCRUNX3RASSF1ARAR-βThbs12-HGIL-6FHITPGE2ICCα-KGGSTCOX-2CCA2-HydroxyglutarateE-cadherinα-ketoglutarateadenomatous polyposis coliHistone modificationinterleukin-6overall survivalthrombospondin 1EMTsuppressor of cytokine signaling 3cyclooxygenase 2Runt-related transcription factor 3DNA methylationEpigenetic regulationMicroRNAMiRNAHCVfragile histidine triaddeath-associated protein kinaseProstaglandin E2Tumor Suppressor Genesepithelial cadherinIntrahepatic cholangiocarcinomaCholangiocarcinomaOpisthorchis viverriniEpithelial-mesenchymal transitionglutathione S-transferasesretinoic acid receptor-β
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Authors
Nai-Jung Chiang, Yan-Shen Shan, Wen-Chun Hung, Li-Tzong Chen,