Decoding mechanisms by which silent codon changes influence protein biogenesis and function

Article ID	Journal	Published Year	Pages	File Type
8322608	The International Journal of Biochemistry & Cell Biology	2015	17 Pages	PDF

Abstract

Synonymous mutations may affect multiple steps of the gene expression process leading to altered phenotype. The primary mechanisms are highlighted with rectangles: incorrect mRNP formation and pre-mRNA processing, mRNA secondary structure alterations, mRNA decay, and altered translation dynamics. CBC: cap binding complex, CDC miRNA: coding sequence binding miRNA, ERAD: endoplasmic reticulum associated degradation, RNase: ribonuclease.

Keywords

E. coli SCC mRNA Catechol-O-methyltransferase TCS CDC NCBI ORF CRISPR-Cas9 GFP ASP C. elegans PHE ALA SRP LEU ESS HEK293 COMT CFTR HEK293T Oct4 Sox2 snRNA DRD2 ACMG TCOF1 THR NANOG PKD2 ESE ncRNA LNs HGPRT tRNA GC3 RNase D. melanogaster MCAD IRGM CCDS PKD1 Hapmap Mfold Polycystin 1 BCL2L12 PARK7 mRNP NBD1 MUPIT ΔF508 precursor mRNA 3′UTR 5′UTR cDNA Complementary DNA DNA messenger RNA small nuclear RNA small non-coding RNA Adenine Arginine Aspartic acid alanine Arg RNA ribonucleic acid deoxyribose nucleic acid Escherichia coli transfer RNA Uracil isoleucine Ile ReST Cho SER Protein folding threonine Codon usage bias Exonic splicing enhancers coding sequence Cub thymine HIS signal recognition particle circular dichroism cystic fibrosis transmembrane conductance regulator ribonuclease Medium-chain acyl-CoA dehydrogenase mRNA structure val CERES Serine human embryonic kidney 293 cell line Lesch–Nyhan syndrome Treacher Collins syndrome three prime untranslated region cytosine SILVA endoplasmic reticulum Exonic splicing silencers octamer-binding transcription factor 4 Phenylalanine open reading frame Pre-mRNA Leucine National Center for Biotechnology Information genome wide association studies GWAS Drosophila melanogaster Micro-RNA MiRNA PRO histidine Valine green fluorescent protein Proline Single nucleotide polymorphism SNP Chinese Hamster Ovary cell line BRCA1 American College of Medical Genetics Caenorhabditis elegans Gly Glycine Guanine dopamine receptor D2