| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8322612 | The International Journal of Biochemistry & Cell Biology | 2015 | 11 Pages |
Abstract
- Control of barriergenesis is provided by glycolysis and is developmentally regulated.
- Pro- or antiangiogenic microenvironment is established due to lactate production.
- Astroglial and endothelial cells regulate lactate transport within the neurovascular unit.
- Reciprocal changes in astroglial and endothelial glycolysis control blood-brain barrier functioning.
Keywords
TFAMHDACAGEsADPNGFWnt-signaling pathwayGSK3PPARgammaPGC-1αTGFSirt1NVUMCTsNRF1WntRAGENFkBVEGFRPDHp53transcription factor A, mitochondrialGPR81HIF-1BDNFNAD(P)NAD(P)HAdenosine TriphosphateATPinterleukinmonocarboxylate transportersCNSBrain developmentBBBcentral nervous systemhypoxia-inducible factor 1Nuclear respiratory factor 1Vascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)nerve growth factorbrain-derived growth factornuclear factor kappa-light-chain-enhancer of activated B cellsLactatelactate dehydrogenaseLDHBlood-brain barrierMethylglyoxalAdvanced glycation end productsNitric oxidenicotinamide adenine dinucleotide (phosphate)histone deacetylaseneurovascular unitpyruvate dehydrogenaseconnexinPeroxisome proliferator-activated receptor gammaglycogen synthase kinase 3GlycolysisReceptor for advanced glycation end productsvascular endothelial growth factor receptor
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Authors
Alla B. Salmina, Natalia V. Kuvacheva, Andrey V. Morgun, Yulia K. Komleva, Elena A. Pozhilenkova, Olga L. Lopatina, Yana V. Gorina, Tatyana E. Taranushenko, Lyudmila L. Petrova,