An essential role of cAMP response element-binding protein in epidermal growth factor-mediated induction of sodium/glucose cotransporter 1 gene expression and intestinal glucose uptake

- EGF-induced glucose uptake is due to changes in the number of SGLT1 molecules.
- An essential CREB binding motif in the SGLT1 promoter for conveying EGF signals.
- CREB phosphorylation is essential for EGF-induced SGLT1 gene expression.
- The EGFR and PI3K pathways are essential in EGF-induced SGLT1 gene expression.
- SGLT1 level is decreased in the inflamed intestine and related with CREB deactivation.