Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8322902 | The International Journal of Biochemistry & Cell Biology | 2014 | 9 Pages |
Abstract
In the present study, we compared the growth of xenograft tumors established from RAGE overexpressing WM115 cells, to that of control cells. We observed that when implanted in mice, RAGE overexpressing cells generated tumors faster than control cells. Analysis of protein tumor extracts showed increased levels of the RAGE ligands S100B, S100A2, S100A4, S100A6 and S100A10 in RAGE overexpressing tumors compared to control tumors. We show that the tumor growth was significantly reduced when the mice were treated with anti-RAGE antibodies, suggesting that RAGE, and probably several S100 proteins, were involved in tumor growth. We further demonstrate that the anti-RAGE antibody treatment significantly enhanced the efficacy of the alkylating drug dacarbazine in reducing the growth rate of RAGE overexpressing tumors.
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Authors
Varsha Meghnani, Anil Wagh, Venkata S.K. Indurthi, Mohit Koladia, Stefan W. Vetter, Benedict Law, Estelle Leclerc,