Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8322973 | The International Journal of Biochemistry & Cell Biology | 2014 | 5 Pages |
Abstract
Physiological electric field (EF) is a potent guidance cue for many physiological development and pathological conditions. The EF induced cellular responses such as migration and proliferation, are considered to be regulated by multiple signaling pathways in a coordinated way. Unlike the signaling transduction regulating the cellular responses toward chemical gradients, the signaling network involved in electric stimulation shows a unique manner, combining the regulation of ion channels, membrane receptors and associated intracellular signaling pathways. This review shall discuss the cellular responses in EF, and summarize the primary signaling network activated during the EF-induced cellular response.
Keywords
CDC42PI3KPIP2PHINADPHNMDARNHEAChRcGMPAP-1PIP3EGFRcAMPERKsMAPKNa+/H+ exchangerNa+/K+-ATPaseNPCsIntracellular pHCyclic adenosine monophosphateCNSNeural progenitor cellscentral nervous systemphosphoinositide 3-kinasecyclic guanosine monophosphatenicotinamide adenine dinucleotide phosphateactivator protein 1cell division control protein 42 homologmitogen-activated protein kinaseextracellular signal-regulated kinasesN-methyl-d-aspartate receptorEpidermal growth factor receptor
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Authors
Qian Liu, Bing Song,