Article ID Journal Published Year Pages File Type
8323241 The International Journal of Biochemistry & Cell Biology 2014 11 Pages PDF
Abstract

- An endogenous cystain-like inhibitor, Trichocystatin-2 (TC-2), was found in Trichomonas vaginalis.
- TC-2 inhibits the proteolytic activity of several cathepsin-L like proteinases of T. vaginalis.
- This inhibitor is a cytoplasmic and lysosomal protein associated with TvCP39.
- This interaction protects host cells from the cytotoxicity of TvCP39.
- We propose that the endogenous cystatins may modulate T. vaginalis pathogenicity mediated by cysteine proteinases.
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