Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8323322 | The International Journal of Biochemistry & Cell Biology | 2014 | 12 Pages |
Abstract
C-reactive protein (CRP), a member of the pentraxin family of plasma proteins, is one of the most distinctive acute phase reactants. In response to inflammation, cell damage or tissue injury, plasma level of CRP rapidly and dramatically increases up to 1000-fold, a phenomenon that has been used for years to monitor infections and many destructive/inflammatory conditions. The magnitude of CRP increase usually correlates with the severity of injury or inflammation and reflects an important physiological role of this interesting but still under-investigated protein. It is now generally accepted that CRP is involved in host defense and inflammation. However, the exact function of this protein in health and disease remains unclear. Many studies have demonstrated that in different pathophysiological conditions CRP might be involved in the regulation of lung function and may participate in the pathogenesis of various pulmonary disorders. The fluctuation of CRP concentrations in both alveolar fluid and serum associated with different pulmonary diseases suggests its important role in lung biology. Discussion of the still controversial functions of CRP in lung physiology and diseases is the main focus of this review.
Keywords
SIRCPEFhsp70FVCBALBHRECPVAPARDSESPfMLPformyl-met-leu-pheLPSsnRNPHfNTNFαHuman plasma fibronectinNF-κBC/EBPMAPKAsthmaSTATinflammationintensive care unitICUbronchiolitis obliteransSCLCCOPDtumor necrosis factor αCHOPPeak expiratory flowForced expiratory volumeLung cancerNSCLCSmall cell lung cancerNon-small cell lung cancerAcute respiratory distress syndromeSystemic inflammatory response syndromebody mass indexBMIPhosphorylcholinephosphocholineFevbronchoalveolar lavagelipopolysaccharideSignal transducer and activator of transcriptionBronchial HyperresponsivenessCCAAT/enhancer-binding proteinheat-shock protein 70C-reactive proteinCRPEosinophil cationic proteinmitogen-activated protein kinaseSingle nucleotide polymorphismVentilator-associated pneumoniaSNP
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Authors
Marianna Agassandian, Galina V. Shurin, Yang Ma, Michael R. Shurin,