| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8323362 | The International Journal of Biochemistry & Cell Biology | 2014 | 11 Pages |
Abstract
We suggest that the physiological and metabolic alterations observed in healthy human primary fibroblasts and endothelial cells are an adaptive response to hyperglycaemia. The severity of metabolic and bioenergetics impairment associated with diabetic complications may occur after longer glucose exposure or due to interactions with cell types more sensitive to hyperglycaemia.
Keywords
HDMECECARΔΨmADPTCAGLUTOCRHDFhyperosmosisPDHNAD+/NADHROSAdenosine TriphosphateATPadenosine diphosphateGlucose transporterelectron transport chainHuman endothelial cellshuman dermal microvascular endothelial cellsHuman dermal fibroblastsHuman fibroblastslactic dehydrogenaseLDHMitochondriaOxygen consumption rateextracellular acidification ratenicotinamide adenine dinucleotideHyperglycaemiaETcMitochondrial transmembrane potentialpyruvate dehydrogenasetricarboxylic acid cycleReactive oxygen species
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Authors
Noah Moruzzi, Marianna Del Sole, Romana Fato, Jantje M. Gerdes, Per-Olof Berggren, Christian Bergamini, Kerstin Brismar,