Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8323449 | The International Journal of Biochemistry & Cell Biology | 2014 | 32 Pages |
Abstract
CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-binding cassette family of membrane proteins. Although almost all members of this family are transporters, CFTR functions as a channel with specificity for anions, in particular chloride and bicarbonate. In this review we look at what is known about CFTR structure and function within the context of the ATP-binding cassette family. We also review current strategies aimed at obtaining the high resolution structure of the protein. This article is part of a Directed Issue entitled: Cystic Fibrosis: From o-mics to cell biology, physiology, and therapeutic advances.
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Authors
Natasha Cant, Naomi Pollock, Robert C. Ford,