In vivo hyperoxia induces hypoxia-inducible factor-1α overexpression in LNCaP tumors without affecting the tumor growth rate

- Effects of systemic hypoxia/hyperoxia (same conditions, only %O2 different) on tumor growth in vivo.
- Hypoxia increases xenografts growth but hyperoxia has no detectable effects.
- HIF-1α higher in hyperoxia than hypoxia.
- Response to redox imbalance higher in hyperoxia.
- Xenografts growth depends more on redox imbalance than HIF-1α signaling.