Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8323611 | The International Journal of Biochemistry & Cell Biology | 2014 | 4 Pages |
Abstract
In conclusion, the results of this study have indicated that although mitochondrial oxidative stress can be attenuated in CoQ10 deficient neurons following CoQ10 supplementation, ETC enzyme activities appear partially refractory to treatment. Accordingly, treatment with >10 μM CoQ10 may be required to restore ETC enzyme activities to control level. Accordingly, these results have important implication for the treatment of the neurological presentations of CoQ10 deficiency and indicate that high doses of CoQ10 may be required to elicit therapeutic efficacy.
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Authors
K.E. Duberley, S.J.R. Heales, A.Y. Abramov, A. Chalasani, J.M. Land, S. Rahman, I.P. Hargreaves,