| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8323906 | The International Journal of Biochemistry & Cell Biology | 2013 | 10 Pages |
Abstract
- We studied the mechanism of antitumor action of the cationic phthalocyanine Pc13.
- Pc13 induced ROS production and the early permeabilization of lysosomal membrane.
- Lysosome disruption was followed by activation of the mitochondrial apoptotic pathway.
- A caspase-dependent apoptotic response was triggered downstream mitochondria damage.
- A model of Pc13-induced apoptotic pathway in KB cells is proposed.
Keywords
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Authors
Julieta Marino, MarÃa C. GarcÃa Vior, Verónica A. Furmento, Viviana C. Blank, Josefina Awruch, Leonor P. Roguin,