Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8323999 | The International Journal of Biochemistry & Cell Biology | 2013 | 16 Pages |
Abstract
Pervasive transcription occurs in the human genome to generate thousands of RNA transcripts, and accumulating evidence suggested that the RNA molecules, without protein coding ability, have important roles in diverse biological functions. Long non-coding RNA (lncRNA), with size larger than 200Â nt, is a new class of the non-coding RNA that contributes to cancer development and progression. Roles for several lncRNAs in cancers have been characterized and strategies targeting them have inhibitory effects to malignant cells in vitro and in vivo. These findings point to the potential of lncRNAs as prospective novel therapeutic targets in cancers. Recent advance in biological drugs, led by nucleic acid drugs (i.e. siRNAs, antisense oligonucleotides), suggest directions for the development of cancer therapies targeting lncRNAs. Here, we discuss the characteristics of lncRNAs regarding their synthesis, stability and functional role in cells, and emphasize their unique properties that determine their molecular functions. We then discuss the association of lncRNAs with cancers, and illustrate the anticancer effects induced upon modulating the level and function of lncRNAs. We also revisit established methods for targeting RNA molecules and discuss new agents and strategies to attenuate lncRNAs in cancer.
Keywords
DM1SELEXshRNAASONATORFdsRNAIRESLSCCHox transcript antisense intergenic RNAlincRNAlncRNAANRILPCGEM1HULCtransactivation response elementlong intergenic non-coding RNACREBantisense non-coding RNA in the INK4 locusatRAHCCantisense oligonucleotidePCAlong non-coding RNARNA interferenceSmall interfering RNAdouble-stranded RNARNAismall hairpin RNAsiRNAall-trans retinoic acidTherapeutic targetsEpigeneticsTarsystematic evolution of ligands by exponential enrichmentEMTRISCmetastasis associated lung adenocarcinoma transcript 1Hammerhead ribozymeRNA secondary structureinternal ribosomal entry siteCancercolorectal carcinomaNSCLCProstate canceropen reading frameMALAT1natural antisense transcriptUTR یا untranslated regions untranslated regionMyotonic dystrophy type 1HOTAIRcAMP-responsive element binding proteinnon-small cell lung carcinomalaryngeal squamous cell carcinomaHepatocellular carcinomaCRCEpithelial–mesenchymal transition
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Authors
Chi Han Li, Yangchao Chen,