| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324070 | The International Journal of Biochemistry & Cell Biology | 2013 | 10 Pages |
Abstract
- The anti-angiogenic and vascular disrupting activities of deoxypodophyllotoxin (DPT) were identified.
- DPT-induced cytoskeleton reorganization is likely contributed to the anti-angiogenic effect.
- The mechanism of DPT-induced G2/M arrest might involve the dysregulation of cyclin B1 and p21.
- DPT exerts the vascular disrupting activity likely via Rho/Rho kinase pathway.
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Authors
Zhenzhou Jiang, Meijuan Wu, Jingshan Miao, Huaqin Duan, Shuang Zhang, Mi Chen, Lixin Sun, Yurong Wang, Xueji Zhang, Xiong Zhu, Luyong Zhang,