| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324152 | The International Journal of Biochemistry & Cell Biology | 2013 | 12 Pages |
Abstract
- A d-amino acid peptide D-PYC98 is a 5-fold more potent JNK inhibitor than L-PYC98.
- D-PYC98 is a pan JNK inhibitor that shows substrate preference.
- The related stress-activated p38α MAPK, but not ERK2 MAPK, is inhibited by D-PYC98.
- Biophysical interaction studies show direct D-PYC98-JNK1 interaction.
- TAT-conjugated D-PYC98 inhibits JNK activity in cells.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Kevin R.W. Ngoei, Bruno Catimel, Nadia Milech, Paul M. Watt, Marie A. Bogoyevitch,