| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324261 | The International Journal of Biochemistry & Cell Biology | 2013 | 8 Pages |
Abstract
⺠T-20S138A, a resistance mutation introduced peptide, blocks T20-resistant HIV-1. ⺠To determine how HIV-1 escapes, we induced T-20S138A-resistant HIV-1 in vitro. ⺠We found that a unique mutation E137K in resistant HIV-1. ⺠E137K introduced T-20S138A suppressed replication of T-20S138A-resistant HIV-1. ⺠Mutations can be consistently useful for the design of peptide inhibitors.
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Authors
Kazuki Izumi, Kumi Kawaji, Fusasko Miyamoto, Kazuki Shimane, Kazuya Shimura, Yasuko Sakagami, Toshio Hattori, Kentaro Watanabe, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka, Mitsuo Kaku, Stefan G. Sarafianos, Eiichi N. Kodama,