Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

Article ID	Journal	Published Year	Pages	File Type
8324369	The International Journal of Biochemistry & Cell Biology	2013	7 Pages	PDF

Abstract

âº Tat induced up-regulation of miR-182 expression. âº miR-182 down-regulate NAMPT and SIRT1 expression. âº miR-182 potentiated Tat-induced activation of HIV transcription.

Keywords

PTM PBEF Pre-B-cell colony-enhancing factor Radioimmune precipitation assay PARPs LTR sirtuin 1 NAMPT PGC-1α RIPA TBS TSA Sirt1 DMEM FBS HDACs BSA Dulbecco's modified Eagle's medium MiR-182 NAD+PPARs q-PCR bovine serum albumin post-translational modification standard deviation TAT Tris-buffered saline Trichostatin A Long terminal repeats fetal bovine serum FoxO nicotinamide adenine dinucleotide nicotinamide phosphoribosyltransferase histone deacetylases quantitative real-time PCR HIV-1 Human immunodeficiency virus type 1 liver X receptor α peroxisome proliferator-activated receptor

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation

Authors

Xin-Yu Chen, Hong-Sheng Zhang, Tong-Chao Wu, Wei-Wei Sang, Zheng Ruan,