| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324394 | The International Journal of Biochemistry & Cell Biology | 2013 | 9 Pages |
Abstract
⺠Long term myriocin treatment increases MRP1 activity in intact cells and membrane vesicles. ⺠This is not due to sphingolipid depletion. ⺠This is not mimicked by addition of glycerophospolipids (allosteric effects). ⺠This is related to lipid raft localization of MRP1. ⺠Michaelis-Menten kinetic analysis reveals an increased Vmax value, but an equal Km value of MRP1 activity.
Keywords
ABCNIHPGPBHK5-CarboxyfluoresceinLTC4FCSHBSSlysophosphatidylethanolamineLPEGlcCerTLCMRP1LacCerABC transporterLC–MSP-glycoproteinsphingomyelinsphingolipidphosphatidic acidCSAbaby hamster kidneyCerceramidefetal calf serumcyclosporin ALiquid chromatography mass spectrometryphosphatidylinositolphosphatidylcholinephosphatidylglycerolphosphatidylethanolaminePhosphatidylserineLipid raftlactosylceramideNational Institutes of HealthHank's balanced salt solutionMyriocinMultidrug Resistance-related Protein 1thin-layer chromatographyATP-binding cassetteglucosylceramide
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Authors
Peter Meszaros, Karin Klappe, Annie van Dam, Pavlina T. Ivanova, Stephen B. Milne, David S. Myers, H. Alex Brown, Hjalmar Permentier, Dick Hoekstra, Jan W. Kok,