Krüppel-like factor 10 upregulates the expression of cyclooxygenase 1 and further modulates angiogenesis in endothelial cell and platelet aggregation in gene-deficient mice

► Studies on vascular development have revealed the crucial role TGF-β plays showing that TGF-β antibodies directly blocked vasculogenesis and angiogenesis. ► Although numerous studies have been done, the role of TGF-β as an angiogenic factor is still unclear. ► Our results provide first evidences to suggest that KLF10, a TGF-β-inducible early gene, regulates COX-1 transcripts expression and further affects tube formation in endothelial cells. ► Moreover, the KLF10 deficient mice exhibited decreased light transmission which represents the extend of platelet aggregation slowing down.