| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324436 | The International Journal of Biochemistry & Cell Biology | 2013 | 10 Pages |
Abstract
⺠The PERK and ATF6 pathway play dominant roles for ER stress-mediated diabetic cardiomyopathy in non-obese type 2 DM. ⺠IRE-1α-XBP1 was not involved in the ER stress-mediated diabetic cardiomyopathy in non-obese type 2 DM. ⺠Differential regulation of UPR might have differential role on lipogenesis regulation.
Keywords
ERSATF6eIF2αGLUT4XBP1GRP78UPRTRAF2SDTCPT1GRP94IRE-1αHDLJnkCHOP/GADD153AMPKc-Jun N-terminal kinaseSprague-Dawleytriglycerideendoplasmic reticulumeukaryotic initiation factor 2 alphaactivated transcription factor 6TNF receptor-associated factor 2high density lipoproteinlow density lipoproteinLDLGlucose transporter type 4body weightUnfolded protein responseX-box binding protein 1protein kinase RNA-like endoplasmic reticulum kinase5′ adenosine monophosphate-activated protein kinasePERKcarnitine palmitoyl transferase 1total cholesterolGlucose regulated protein 94glucose regulated protein 78
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Authors
Arun Prasath Lakshmanan, Meilei Harima, Kenji Suzuki, Vivian Soetikno, Masaki Nagata, Takashi Nakamura, Toshihiro Takahashi, Hirohito Sone, Hiroshi Kawachi, Kenichi Watanabe,