| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324455 | The International Journal of Biochemistry & Cell Biology | 2013 | 8 Pages |
Abstract
⺠GLP-1 increased glucose-stimulated insulin secretion under glucotoxic conditions. ⺠GLP-1 preferentially stimulates PKA as a result from elevation of cAMP. ⺠The GLP-1 action was blocked by the PKA inhibitor Rp-cAMPS. ⺠GLP-1 failed to potentiate insulin secretion in the presence of the PKA agonist. ⺠Knockdown or maximally activation of Epac2 does not interfere with GLP-1 actions.
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Authors
Guochun Luo, Xiangchen Kong, Lina Lu, Xiaohui Xu, Hui Wang, Xiaosong Ma,