| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324480 | The International Journal of Biochemistry & Cell Biology | 2013 | 8 Pages |
Abstract
Mechanisms of the tumor cells to avoid the immune attack. Tumor cells produce or sequester several metabolites to prevent the immune recognition: aminoacids (tryptophan, l-arginine and peroxynitrite (PNT)), lipid metabolism (cholesterol and oxysterol) and lactate. Also tumor metabolism downregulates the expression of MHC-I, which helps tumor cells to avoid recognition by CTLs.
Keywords
MDSCsHIF-1αIFN-γIDOTregPLGGTNERKNHLTCrMICSOXPHOSTCAPSAPNTCancer immunosurveillanceLXRPDK1MHC-IAPMTGF-βDCAnatural killerCTLsMAPKPPARsROSHuman leukocyte antigentumor-associated antigenHLAWarburg effecttricarboxylic acidinterferon-γindoleamine 2,3-dioxygenasetransforming growth factor-βPositron emission tomographyTAAsDichloroacetateCancer immunoeditingcytotoxic T-cellsDendritic cellsMyeloid-derived suppressor cellsRegulatory T cellsbody mass indexBMIhypoxia inducible factor 1αOxidative phosphorylationnon-Hodgkin's lymphomaAntigen processing machinerymaphistone acetyltransferasesprostate-specific antigenPETmitogen-activated proteinPeroxynitriteHATextracellular signal-regulated kinasesKinasesGlyceryl trinitrateReactive oxygen speciesT cell receptorLiver X receptors
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Authors
Martin Villalba, Moeez G. Rathore, Nuria Lopez-Royuela, Ewelina Krzywinska, Johan Garaude, Nerea Allende-Vega,