Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8324491 | The International Journal of Biochemistry & Cell Biology | 2012 | 4 Pages |
Abstract
Airways consist of a heterogeneous population of cells, comprising ciliated cells, Clara cells and goblet cells. Electrolyte secretion by the airways is necessary to produce the airway surface liquid that allows for mucociliary clearance of the lungs. Secretion is driven by opening of Clâ selective ion channels in the apical membrane of airway epithelial cells, through either receptor mediated increase in intracellular cAMP or cytosolic Ca2+. Traditionally cAMP-dependent and Ca2+-dependent secretory pathways are regarded as independent. However, this concept has been challenged recently. With identification of the Ca2+ activated Clâ channel TMEM16A (anoctamin 1) and with detailed knowledge of the cAMP-regulated cystic fibrosis transmembrane conductance regulator (CFTR), it has become possible to look more closely into this relationship.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Karl Kunzelmann, Yuemin Tian, Joana Raquel Martins, Diana Faria, Patthara Kongsuphol, Jiraporn Ousingsawat, Luisa Wolf, Rainer Schreiber,