| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324513 | The International Journal of Biochemistry & Cell Biology | 2012 | 10 Pages |
Abstract
⺠Delineation of multiple deregulated metabolic events in head and neck squamous cell carcinoma (HNSCC). ⺠Glutaminolysis, a major carbon source in HNSCC. ⺠HNSCC highlighted with altered levels of choline containing metabolites and phospholipase A2, particulary cytosolic PLA2 (cPLA2) revealing altered membrane choline phospholipid metabolism. ⺠Adaptive mechanism of HNSCC to osmotic and oxidative stress. ⺠cPLA2, a potential therapeutic target.
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Authors
Pratima Tripathi, Pachiyappan Kamarajan, Bagganahalli S. Somashekar, Neil MacKinnon, Arul M. Chinnaiyan, Yvonne L. Kapila, Thekkelnaycke M. Rajendiran, Ayyalusamy Ramamoorthy,