Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8324642 | The International Journal of Biochemistry & Cell Biology | 2012 | 10 Pages |
Abstract
Toll-like receptors are well known as molecular sensors of pathogen-associated molecular patterns. They control activation of the innate immune response and subsequently shape the adaptive immune response. Recent publications have demonstrated that Toll-like receptors also play important roles in multiple human cancers, yet their function in oral squamous cell carcinoma remains unclear. In this study, we showed that both oral squamous cell carcinoma cell lines and tissues from oral squamous carcinoma patients express relatively high levels of Toll-like receptor 3. We also found that synthetic dsRNA-polyinosinic-polycytidilic acid, a Toll-like receptor 3 ligand, induced apoptosis of oral squamous carcinoma cells mainly via Toll-like receptor 3, through interferon-β production and activation of caspases 3 and 9. Moreover, in an oral squamous cell carcinoma xenograft mouse model, we demonstrated for the first time that activation of Toll-like receptor 3 inhibited oral squamous cell carcinoma tumor growth in vivo. Therefore, the direct proapoptotic activity of Toll-like receptor 3 in human oral squamous carcinoma cells may make this protein a viable therapeutic target in the treatment of oral squamous cell carcinoma.
Keywords
DCsTLR3dsRNAPRRRIG-IIAPSPKCMDA5IFN-βIRFsOSCCLGP2Small interfering RNAdouble-stranded RNAsiRNATRIFlaboratory of genetics and physiology 2Interferon-βTUNELApoptosisDendritic cellsendoplasmic reticuluminhibitor of apoptosis proteinsProtein kinase CPoly I:Cmelanoma differentiation-associated gene 5retinoic acid-inducible gene Ioral squamous cell carcinomacaspase 3pattern recognition receptorsToll-like receptor 3
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Authors
Qingqiong Luo, Shuiqing Hu, Ming Yan, Zujun Sun, Wantao Chen, Fuxiang Chen,