| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8324666 | The International Journal of Biochemistry & Cell Biology | 2012 | 9 Pages |
Abstract
⺠The expression of S100A4 is induced in the rhomboid VSMCs by hypoxia. ⺠IL-6/JAK2/STAT3 pathway can regulate the phenotype of hypoxic VSMCs. ⺠HIF-1 can regulate the phenotype of VSMCs exposure to hypoxia. ⺠Hypoxic VSMCs proliferation is controlled by S100A4 via HIF-1/JAK2/STAT3 pathway.
Keywords
ERKPASMCsVSMCsS100A4JAK2STAT3HIF-1PBSPAHDMEMBSADulbecco's modified Eagle MediumJAKsshort hairpin RNAsiRNASTATsbovine serum albuminProliferationPulmonary arterial smooth muscle cellsVascular smooth muscle cellsPhosphate buffered salinePulmonary arterial hypertensionsignal transducers and activators of transcriptionPhenotypic modulationHypoxiaJanus kinasesextracellular signal-regulated kinase
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Ting Liu, Yuncheng Li, Kexiong Lin, Hongjin Yin, Binfeng He, Michael Zheng, Guansong Wang,