Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8325068 | The International Journal of Biochemistry & Cell Biology | 2011 | 4 Pages |
Abstract
It is well-known that cell cycle arrest and/or death play a pivotal role in tumor progression, which has drawn a rising attention for cancer biologists due to their complex and intricate relationships. In this review, we demonstrate the recent research on oridonin, an active diterpenoid with remarkable anti-proliferative activities, and then further explore its molecular mechanisms of cell cycle arrest, apoptosis, autophagy and their cross-talks in various cancer cells, which may provide a new perspective of oridonin as a candidate anti-neoplastic drug for future cancer therapeutics.
Keywords
PTKNF-κBPI3KJnkERKEGFRPCDc-Jun N-terminal kinaseMAPKOridoninAktAutophagyCell cycle arrestApoptosisFas LigandFasLnuclear factor kappa BPhosphatidylinositol 3-kinaseProgrammed cell deathProtein tyrosine kinaseprotein kinase Bmitogen activated protein kinaseextracellular-regulated kinaseEpidermal growth factor receptor
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Authors
Chun-yang Li, En-qin Wang, Yan Cheng, Jin-ku Bao,