Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8325519 | The International Journal of Biochemistry & Cell Biology | 2010 | 6 Pages |
Abstract
Our explorative pathway analysis on seven published gene-sets associated with platinum resistance in ovarian cancer reveals TP53 and transforming growth factor beta as key genes. Furthermore, the extracellular matrix was associated with chemotherapy resistance in ovarian cancer as well as endocrine resistance in breast cancer. Pathway analysis again revealed transforming growth factor beta as a key gene regulating extracellular matrix gene expression. A model is presented based on literature linking transforming growth factor beta, extracellular matrix, integrin signalling, epithelial to mesenchymal transition and regulating microRNAs with a (bivalent) role in chemotherapy response.
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Authors
Jozien Helleman, Maurice P.H.M. Jansen, Curt Burger, Maria E.L. van der Burg, Els M.J.J. Berns,