Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8325785 | The International Journal of Biochemistry & Cell Biology | 2009 | 10 Pages |
Abstract
Current evidence supports the therapeutic potential of pharmacological interventions that counter the progression of genetic disorders by promoting regeneration of the affected organs or tissues. The rationale behind this concept lies on the evidence that targeting key events downstream of the genetic defect can compensate, at least partially, the pathological consequence of the related disease. In this regard, the beneficial effect exerted on animal models of muscular dystrophy by pharmacological strategies that enhance muscle regeneration provides an interesting paradigm. In this review, we describe and discuss the potential targets of pharmacological strategies that promote regeneration of dystrophic muscles and alleviate the consequence of the primary genetic defect. Regenerative pharmacology provides an immediate and suitable therapeutic opportunity to slow down the decline of muscles in the present generation of dystrophic patients, with the perspective to hold them in conditions such that they could benefit of future, more definitive, therapies.
Keywords
PCAFGSK3bHLHAT1IKKDAPCDMDrAAVPIGFIKBJun N-terminal kinasePI3KInhibitor of NF-kBFKRPGDF-8GRB2SarcoglycansIkB kinaseFLRGAngiotensin receptor 1TGF-βactivin type II receptorBMP4JnkMPCNF-kBnNOSMMP-9HDACSCGIGF-IDGCCDKsAktinflammationinsulin-like growth factor IRegenerationtransforming growth factor-βtumor necrosis factor-αMuscular dystrophiesDuchenne muscular dystrophyMuscular dystrophyMuscle progenitor cellsneuronal nitric oxide synthaseP300/CBP-associated factorTNF-αNuclear factor-kappa BFoxOPhosphatidylinositol 3-kinaseMatrix metalloproteinase-9Dystrophin-glycoprotein complexSignaling pathwaysCyclin-dependent kinase inhibitorsNitric oxideHistone acetyltransferasehistone deacetylaserecombinant adeno-associated virusdystrophin-associated protein complexChromatinSerine-threonine kinaseHAT
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Authors
Chiara Mozzetta, Giulia Minetti, Pier Lorenzo Puri,