| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8325821 | The International Journal of Biochemistry & Cell Biology | 2009 | 4 Pages |
Abstract
CCL2 DNA vaccines are directed against the host chemoattractant molecule CCL2 (MCP-1), a key chemokine in recruiting macrophages to sites of inflammation. Macrophages recruited by CCL2 lead to progressive renal injury. In rat models of disease unmodified CCL2 DNA vaccine in combination with a CCL5 (RANTES) DNA vaccine can protect against chronic renal disease. The mechanism of protection involves the induction of auto-antibodies to the CCL2. Introduction of the adjuvant p-tet into the DNA structure of the CCL2 vaccine leads to enhanced potency with the induction of specific Th1 cellular immunity. The strategies outlined here demonstrate a model for developing potent vaccines against highly restricted self targets.
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Authors
Debbie Watson, Guoping Zheng, Huiling Wu, Yuan Min Wang, Yiping Wang, David C.H. Harris, S.I. Alexander,