The soluble transforming growth factor-β receptor: Advantages and applications

Transforming growth factor-beta (TGF-β) is a cytokine that plays a pivotal role in growth, differentiation, development, immune response and wound healing. TGF-β is upregulated following wound infliction and inflammation, and plays an important role in the production of extracellular matrix proteins that contribute to tissue repair. However, in some diseases, TGF-β dysregulation can lead to tumor formation, organ fibrosis and the disruption of organ function. A number of molecules have been designed to counteract the effects of TGF-β, including anti-TGF-β monoclonal antibodies and various small molecules. Here we discuss the design, use and advantages of the highly specific TGF-β binding molecule, the soluble human TGF-β receptor (sTβR.Fc) as a TGF-β sequestering agent.