Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures

Article ID	Journal	Published Year	Pages	File Type
8326169	The International Journal of Biochemistry & Cell Biology	2009	9 Pages	PDF

Abstract

All these observations allow us to state that, in the presence of calcium, Co2+ is an inducer of apoptosis triggered by mitochondrial oxidative stress.

Keywords

HIF-1 BKA Cyt C APF MPT TBARS DTE NAC RLM BHT dithioerythritol DMF ADNT N-acetylcysteine ROS Δψ AIF Bongkrekic acid mitochondrial permeability transition CSA butylhydroxytoluene adenine nucleotide translocase Oxidative stress Apoptosis dimethyl formamide ruthenium red cytochrome c cyclosporin A apoptosis inducing factor hypoxia-inducible factor-1 Rat liver mitochondria Membrane potential Cobalt thiobarbituric acid-reactive species Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures

Authors

Valentina Battaglia, Alessandra Compagnone, Andrea Bandino, Marcantonio Bragadin, Carlo Alberto Rossi, Filippo Zanetti, Sebastiano Colombatto, Maria Angelica Grillo, Antonio Toninello,