Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8326636 | International Journal of Biological Macromolecules | 2018 | 28 Pages |
Abstract
We report a new drug-loaded film for blending poly(L-lactide) (PLLA) with lignin-based functional filler, which enhanced stability and sustained release of trans-resveratrol (trans-RSV). In addition, trans-RSV loaded PLLA/lignin films showed good antioxidant and anticancer effects. Incorporation of the optimized amount of lignin-based filler to PLLA matrix was key to achieve these desired functions. The lignin-based filler (LG-g-PDLA) was synthesized via ring-opening polymerization on alklin lignin with D-lactide. Benifiting from the stereocomplex formation (PLLA and PDLA side chains), similar polyphenolic structures between lignin and trans-RSV, and UV chromophoric groups of lignin, trans-RSV loaded PLLA/lignin-graft-PDLA films (R/P/LGPD) have good performances on mechanical property, uniformity distribution of drug, and light barrier property. The release behaviors of trans-RSV could be controlled by variation of LG-g-PDLA content. This system therefore offers great potential for the delivery of poor water soluble and light stability drugs.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Rui Liu, Lin Dai, Zhufan Zou, Chuanling Si,